Elsevier

Schizophrenia Research

Volume 192, February 2018, Pages 489-490
Schizophrenia Research

Letter to the Editor
The effect of transcranial direct current stimulation on auditory hallucination in patients with schizophrenia

https://doi.org/10.1016/j.schres.2017.06.012Get rights and content

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Contributors

Authors Jun Soo Kwon and Tae Young Lee were responsible for the design of the whole study and wrote the protocol. Author Tae Young Lee wrote the manuscript. Authors Tae Young Lee, Junhee Lee, and Minah Kim supported the analysis, interpretation and manuscript revision. All authors contributed and approved the final manuscript.

Role of funding source

This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (NRF-2015R1C1A1A01053988) and (NRF-2017M3C7A1029610).

Conflict of interest

None.

Acknowledgement

We thank In-Young Ahn, Shin-ae Yeom for literature searching. We also thank the authors of the study that sent the necessary details for the analysis.

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  • A meta-analysis of transcranial direct current stimulation for schizophrenia: “Is more better?”

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    Meta-regression analyses suggest a negative association between age and the SMDs for both auditory hallucinations and negative symptoms. Our results are consistent with the findings from a recently published meta-analysis of open-labelled and sham-controlled studies investigating the effect of tDCS on auditory hallucinations in patients with schizophrenia (Lee et al., 2018). Relatedly, studies using a TMS paired-associated stimulation (PAS) technique in healthy adults showed that the magnitude of PAS-induced plasticity in the motor cortex was greater in younger participants (Muller-Dahlhaus et al., 2008).

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    One open-label study to date has shown the beneficial effects of long-term tDCS [24]. More recently, Lee et al. [25] reported positive effects from conducting a meta-analysis of existing studies on the efficacy of tDCS on hallucinations in individuals with schizophrenia. Further, another recent meta-analysis [26] of tDCS effects on psychosis symptom dimensions reported significant effects on negative symptoms and auditory hallucinations, but not on positive symptoms.

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