Archival ReportMicrostructural Changes in Higher-Order Nuclei of the Thalamus in Patients With First-Episode Psychosis
Section snippets
Methods and Materials
Thirty-seven patients with FEP were selected, between April 2010 and June 2014, from a slightly larger pool of patients who visited Seoul National University Hospital for their symptoms and agreed to participate in the research. Intensive clinical interviews were conducted for all patients with FEP by experienced psychiatrists, using the Structured Clinical Interview for DSM-IV-TR Axis I Disorders (SCID-I) to identify past and current psychiatric illnesses. The inclusion criteria were age
Results
There were no significant differences in the demographic backgrounds between the patients with FEP and the HCs, except for their IQ scores (t71 = 2.86, p < .05) (Table 1).
The results of ANCOVA of the MKs are summarized in Table 2. There was a significant group effect on the MKs, in which patients with FEP exhibited reduced MKs in the thalamic ROIs with the strongest connections to the OFC (F1,70 = 8.40, p < .01) and the LTC (F1,70 = 8.46, p < .005). The group effect on other thalamic nuclei did
Discussion
To our knowledge, this is the first study to report nuclei-specific microstructural alterations in the thalamus of patients with FEP. Our results revealed significantly reduced microstructural complexity in the thalamic regions with strong connections to the OFC and LTC in patients with FEP. By using measures of microstructure in vivo, our results could show that the nuclei-specific abnormalities in the thalamus exist from the early stages of the disorder, findings that have been somewhat
Acknowledgments and Disclosures
This research was supported by the Brain Research Program through the National Research Foundation of Korea funded by the Ministry of Science, Information and Communication Technologies, and Future Planning (Grant No. 2017M3C7A1029610 [to JSK]). The authors report no biomedical financial interests or potential conflicts of interest.
References (86)
- et al.
Updated meta-analyses reveal thalamus volume reduction in patients with first-episode and chronic schizophrenia
Schizophr Res
(2010) - et al.
Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia
J Psychiatr Res
(2010) - et al.
Abnormalities in the thalamus and prefrontal cortex during episodic object recognition in schizophrenia
Biol Psychiatry
(2000) - et al.
Increased hemodynamic response in the hippocampus, thalamus and prefrontal cortex during abnormal sensory gating in schizophrenia
Schizophr Res
(2007) - et al.
Mapping Thalamocortical Functional Connectivity in Chronic and Early Stages of Psychotic Disorders
Biol Psychiatry
(2016) - et al.
Prefrontal-Thalamic Anatomical Connectivity and Executive Cognitive Function in Schizophrenia
Biol Psychiatry
(2018) - et al.
Postmortem structural studies of the thalamus in schizophrenia
Schizophr Res
(2017) - et al.
Reduction of right medial pulvinar volume and neuron number in schizophrenia
Schizophr Res
(2007) - et al.
Volumetric abnormalities in connectivity-based subregions of the thalamus in patients with chronic schizophrenia
Schizophr Res
(2007) - et al.
Magnetic resonance imaging and spectroscopy reveal differential hippocampal changes in anhedonic and resilient subtypes of the chronic mild stress rat model
Biol Psychiatry
(2011)
Does diffusion kurtosis imaging lead to better neural tissue characterization? A rodent brain maturation study
Neuroimage
Global assessment of functioning. A modified scale
Psychosomatics
Within-subject template estimation for unbiased longitudinal image analysis
Neuroimage
Improved optimization for the robust and accurate linear registration and motion correction of brain images
Neuroimage
A global optimisation method for robust affine registration of brain images
Med Image Anal
Probabilistic diffusion tractography with multiple fibre orientations: What can we gain?
Neuroimage
FSL
Neuroimage
Reduced number of mediodorsal and anterior thalamic neurons in schizophrenia
Biol Psychiatry
Reduced sleep spindle activity point to a TRN-MD thalamus-PFC circuit dysfunction in schizophrenia
Schizophr Res
Reduced sleep spindles and spindle coherence in schizophrenia: Mechanisms of impaired memory consolidation?
Biol Psychiatry
Volume reduction and altered sulco-gyral pattern of the orbitofrontal cortex in first-episode schizophrenia
Schizophr Res
Reduced cortical thickness in first episode schizophrenia
Schizophr Res
Sulcogyral patterns and morphological abnormalities of the orbitofrontal cortex in psychosis
Prog Neuropsychopharmacol Biol Psychiatry
Performances of diffusion kurtosis imaging and diffusion tensor imaging in detecting white matter abnormality in schizophrenia
Neuroimage Clin
Abnormal hemodynamics in schizophrenia during an auditory oddball task
Biol Psychiatry
Pronounced reduction of total neuron number in mediodorsal thalamic nucleus and nucleus accumbens in schizophrenics
Arch Gen Psychiatry
Recent advances in the neuropathology of schizophrenia
Schizophr Bull
Magnetic resonance imaging of the brain in schizophrenia. The pathophysiologic significance of structural abnormalities
Arch Gen Psychiatry
Effects of diagnosis, laterality, and gender on brain morphology in schizophrenia
Am J Psychiatry
Brain volumes in schizophrenia: A meta-analysis in over 18 000 subjects
Schizophr Bull
Glutamatergic abnormalities of the thalamus in schizophrenia: A systematic review
J Neural Transm (Vienna)
Schizophrenia and cognitive dysmetria: A positron-emission tomography study of dysfunctional prefrontal-thalamic-cerebellar circuitry
Proc Natl Acad Sci U S A
Three-dimensional analysis with MRI and PET of the size, shape, and function of the thalamus in the schizophrenia spectrum
Am J Psychiatry
The role of the thalamus in schizophrenia
Can J Psychiatry
Thalamocortical dysconnectivity in schizophrenia
Am J Psychiatry
Thalamocortical disconnection in the orbitofrontal region associated with cortical thinning in schizophrenia
JAMA Psychiatry
Association of thalamic dysconnectivity and conversion to psychosis in youth and young adults at elevated clinical risk
JAMA Psychiatry
Altered thalamo-cortical white matter connectivity: probabilistic tractography study in clinical-high risk for psychosis and first-episode psychosis
Schizophr Bull
Resting-state thalamic dysconnectivity in schizophrenia and relationships with symptoms
Psychol Med
The Thalamus, 2nd ed
Basal ganglia and limbic system pathology in schizophrenia. A morphometric study of brain volume and shrinkage
Arch Gen Psychiatry
Postmortem assessment of thalamic nuclear volumes in subjects with schizophrenia
Am J Psychiatry
Dissociable roles for cortical and subcortical structures in memory retrieval and acquisition
J Neurosci
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