클리닉소개

THE SEOUL YOUTH CLINIC

연구 및 치료성과

Cortical thickness in obsessive–compulsive disorder: multisite mega-analysis of 780 brain scans from six centres
Journal
The British Journal of Psychiatry
Vol
210: 1
Page
67-74
Author
Jean-Paul Fouche, Stefan du Plessis, Coenie Hattingh, Annerine Roos, Christine Lochner, Carles Soriano-Mas, Joao R Sato, Takashi Nakamae, Seiji Nishida, Jun Soo Kwon, Wi Hoon Jung, David Mataix-Cols, Marcelo Q Hoexter, Pino Alonso, OCD Brain Imaging Conso
Year
2018

Background

There is accumulating evidence for the role of fronto-striatal and associated circuits in obsessive–compulsive disorder (OCD) but limited and conflicting data on alterations in cortical thickness.


Aims

To investigate alterations in cortical thickness and subcortical volume in OCD.


Method

In total, 412 patients with OCD and 368 healthy adults underwent magnetic resonance imaging scans. Between-group analysis of covariance of cortical thickness and subcortical volumes was performed and regression analyses undertaken.


Results

Significantly decreased cortical thickness was found in the OCD group compared with controls in the superior and inferior frontal, precentral, posterior cingulate, middle temporal, inferior parietal and precuneus gyri. There was also a group x age interaction in the parietal cortex, with increased thinning with age in the OCD group relative to controls.


Conclusions

Our findings are partially consistent with earlier work, suggesting that group differences in grey matter volume and cortical thickness could relate to the same underlying pathology of OCD. They partially support a frontostriatal model of OCD, but also suggest that limbic, temporal and parietal regions play a role in the pathophysiology of the disorder. The group x age interaction effects may be the result of altered neuroplasticity.